Research
Tissue Repair, Fibrosis, Metabolism, and inter-organ communication
01
Metabolic control of tissue repair
Metabolic pathways as regulators of disease and recovery
We investigate how NAD, adenine, and nucleotide metabolism, and related metabolic pathways regulate cellular stress responses, cardiac function, and renal injury and repair. A central goal is to identify metabolic mechanisms that can be therapeutically targeted to restore tissue homeostasis in cardiometabolic and renal disease.
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J Clin Invest. 2022 Jan 18;132(2):e156296.
02
Inter-organ communication & regenerative biology
How one organ influences the repair of another
We investigate how organs communicate through circulating proteins and other signals to coordinate tissue responses to injury. Our work explores the kidney as an endocrine regulator of cardiac repair, and seeks to uncover new biological pathways that can be harnessed to promote recovery across organ systems.
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03
Therapeutic discovery & human disease modeling
From fundamental mechanisms to new medicines
We translate discoveries in injury, metabolism, and repair into therapeutic strategies for cardiovascular and renal diseases. Our work integrates biologic drug development and clinical investigation with human induced pluripotent stem cell (hiPSC) models to understand metabolic interactions among cell types and test disease-relevant mechanisms.
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Cell Rep Med. 2024 Nov 19;5(11):101795.
04
Fibrosis, extracellular matrix and pathological remodeling
Why injured tissues heal — or develop chronic disease
We study how interactions between cardiac myocytes, fibroblasts, and other cell populations shape tissue remodeling after injury. In parallel, we investigate the mechanisms of pathological mineralization, including ectopic calcification in ABCC6 deficiency and calciphylaxis.
Cell. 2020 Aug 6;182(3):545-562.e23.
05
Scar biology & cardiac arrhythmias
How scar tissue shapes cardiac electrical activity
We investigate how fibroblasts and cardiomyocytes interact within cardiac scar tissue to regulate cardiac excitability and arrhythmogenesis. Our work focuses on the cellular and biophysical mechanisms of fibroblast–myocyte electrical coupling and how these interactions influence cardiac electrical activity after injury. A central goal is to identify new therapeutic targets for scar-related arrhythmias.
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Science. 2023 Sep 29;381(6665):1480-1487.