Selected Publications (Click to read On PubMed)

Li S, Ma F, Yokota T, Garcia G Jr, Palermo A, Wang Y, Farrell C, Wang YC, Wu R, Zhou Z, Pan C, Morselli M, Teitell MA, Ryazantsev S, Fishbein GA, Ten Hoeve J, Arboleda VA, Bloom J, Dillon BJ, Pellegrini M, Lusis AJ, Graeber TG, Arumugaswami V, Deb A. Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2 induced systemic toxicity. JCI Insight. 2020 Dec 7;. doi: 10.1172/jci.insight.145027. [Epub ahead of print] [PMID: 33284134]

Yang H, Sun L, Cai W, Gu J, Xu D, Deb A*, Duan J*. DDR2, a discoidin domain receptor, is a marker of periosteal osteoblast and osteoblast progenitors. Journal of Bone and Mineral Metabolism. 2020 May 15;. doi: 10.1007/s00774-020-01108-y. [Epub ahead of print] [PMID: 32415375]. (*Co-corresponding authors) 

Wu R, Ma F, Tosevska A, Farrell C, Pellegrini M, Deb A. Cardiac fibroblast proliferation rates and collagen expression mature early and are unaltered with advancing age. JCI Insight. 2020 Nov 12:140628. doi: 10.1172/jci.insight.140628. Epub ahead of print. [PMID: 33180747]

Yokota T, McCourt J, Ma F, et al., Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury, Cell (2020), [PMID: 32621799]

Deb A. How Stem Cells Turn into Bone and Fat. N Engl J Med. 2019 Jun 6;380(23):2268-2270. doi: 10.1056/NEJMcibr1905165. [PMID: 31167059; PMCID: PMC6901025]

Huo R, Hu C, Zhao L, Sun L, Wang N, Lu Y, Ye B, Deb A, Li F, Xu H. Enhancement of β-catenin/T-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by suppressing NaV1.5 expression in mice. Heart Rhythm. 2019. S1547-5271(19)30456-4. [PMID: 31125668]​

Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A. Endocardially Derived Macrophages Are Essential for Valvular Remodeling. Developmental Cell. 2019 Mar;48(5):617-630.e3. Epub 2019 Feb. [PMID: 30799229]

Lin LY, Chun Chang S, O'Hearn J, Hui ST, Seldin M, Gupta P, Bondar G, Deng M, Jauhiainen R, Kuusisto J, Laakso M, Sinsheimer JS, Deb A, Rau C, Ren S, Wang Y, Lusis AJ, Wang JJ, Huertas-Vazquez A. Systems Genetics Approach to Biomarker Discovery: GPNMB and Heart Failure in Mice and Humans. G3 (Bethesda). 2018 Nov;8(11):3499-3506. [PMID: 30201759]

Yu J, Seldin MM, Fu K, Li S, Lam L, Wang P, Wang Y, Huang D, Nguyen TL, Wei B, Kulkarni RP, Di Carlo D, Teitell M, Pellegrini M, Lusis AJ, Deb A, Topological Arrangement of Cardiac Fibroblasts Regulates Cellular Plasticity. Circulation Research. 2018;123:73–85; [PMID:29691232]

Foulquier S, Daskalopoulos EP, Lluri G, Hermans KCM, Deb A, Blankesteijn WM. Wnt signaling in cardiac and vascular disease. Pharmacological Reviews. 2018; 70(1):68-141. [PMID:29247129]


Lluri G., Renella P., Finn J., Vorobiof G., Aboulhosn J., Deb A.,  Prognostic Significance of Left Ventricular Fibrosis in Patients With Congenital Bicuspid Aortic Valve. The American journal of Cardiology (2017); 120(7):1176-1179.

Monaghan, M. G., Holeiter, M., Brauchle, E., Layland, S. L., Lu, Y., Deb, A., Abhay, P., All, N., KatJa, S.,  Schenke-Layland, K. Exogenous miR-29B Delivery Through a Hyaluronan-Based Injectable System Yields Functional Maintenance of the Infarcted Myocardium. Tissue Engineering Part A, 2017


Seldin, M. M., Kim, E. D., Romay, M. C., Li, S., Rau, C. D., Wang, J. J., Krishnan, K.C., Wang, Y., Deb, A.,  Lusis, A. J. A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. American Journal of Physiology - Heart and Circulatory Physiology, 2017; 312(4): H728-H741.

Pillai I, Li S, Romay M, Lam L, Lu Y, Jie Huang, Dillard N, Zemanova M, Rubbi L, Wang Y, Lee J, Xia M, Liang O, Xie Y, Pellegrini M, Lusis A, Deb A. Cardiac fibroblasts adopt osteogenic cell fates and can be targeted to attenuate pathological heart calcification. Cell Stem Cell, 2017; 20(2):218-232 [epub] [Highlighted by Science magazine]

Murray IR, Baily J, Chen WCW, Dar A, Gonzalez ZN, Jensen AR, Petrigliano FR, Deb A*, Henderson NC*. Skeletal and Cardiac Muscle Pericytes: Functions and Therapeutic Potential. Pharmacology and Therapeutics, 2017; 171:65-74  *corresponding author/senior authors

Wang Z,  Zhang X,  Ji Y, Zhang P, Deng K, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang Y, Li S, Cass A, Vondriska V, Li G, Deb A, Srivastava D, Yang H, Xiao X, Li H, Wang YA long non-coding RNA defines an epigenetic checkpoint for cardiac hypertrophy. Nature Medicine. 2016; 22 (10):1131-1139 [PMCID 5053883]

Brumm A, Nunez S, Doroudchi M, Kawaguchi R, Duan J, Pellegrini M, Lam L, Carmichael T, Deb A*, Hinman J*. Astrocytes can adopt endothelial cell fates in a p53 dependent manner. Molecular Neurobiology, [2016] *corresponding authors


Deb A. Wang Y. Hypertrophic preconditioning: short-term tricks for long-term gain. Circulation, 2015; 131(17):1468-1470

Ubil E, Duan J, Pillai I, Rosa-Garrido M, Wu Y, Bargiacchi F, Lu Y, Stanbouly S, Huang J, Rojas M, Vondrinska T, Stefani E & Deb A. Mesenchymal-endothelial transition contributes to cardiac neovascularization.
Nature,  2014; 514:585-90 [PMID 25317562]

Deb A. Cell-Cell Interaction via the Wnt/β-catenin pathway after cardiac injury. Cardiovasc Res, 2014  [PMID 24591151]

Deb A, Ubil E.  Cardiac Fibroblast in Development and Wound healing.
J Mol Cell Cardiol, 2014.     . [PMID 24625635]

Duan J, Lee Y, Jania C, Gong J, Rojas M, Burk L, Willis M, Homeister J, Tilley S, Rubin J, Deb A. Rib fractures and death from rapid osteoclastogenesis is rescued by corticosteroids
PLoS ONE, 2013; 8(2): e55757.[PMID 23393600]

Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan J, Rojas M, Willis, M, Leask A, Majesky M, Deb A. Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts and is critical for cardiac repair
EMBO J, 2011; 31(2):429-442 [PMID 22085926] (This manuscript won the Katz Basic Science Research award at AHA, Scientific sessions, Chicago, 2010)

Gherghe C, Duan J, Gong J, Rojas M, Klauber-More N, Majesky M, Deb A. Wnt1 is a pro-angiogenic molecule, enhances human endothelial progenitor function and increases blood flow to ischemic limbs in a HGF dependent manner.
FASEB J 2011; 25:1836-1843 [PMID 21321190]

Deb A, Patterson C. Closer to fine: Fewer Steps to endothelial stemness.
Arterioscler Thromb Vasc Biol. 2010. (10):1880-1. [PMID 20844268]

Huang J, Zhang Z, Guo J, Ni A, Deb A, Zhang L, Mirotsou M, Pratt RE, Dzau VJ. Genetic Modification of Mesenchymal Stem Cells Overexpressing CCR1 Increases Cell Viability, Migration, Engraftment, and Capillary Density in the Injured Myocardium.
Circ Res 2010; 106(11) 1753-62. [PMID 20378860]

Deb A, Patterson C. Hard Luck Stories: The Reality of Endothelial Progenitor Cells Continues to Fall Short of the Promise.
Circulation 2010;121:850-852 [PMID 20142453]

Zhang Z, Deb A, Zhang Z, Pachori A, We H, Guo J, Pratt R, Dzau VJ. Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a.
J Mol Cell Cardiol 2009 46(3):370-7 [PMID 19109969]

Deb A*, Guo J, Ni A, Davis B, Huang J, Zhang J, Mu H, Dzau V J. SFRP2 regulates cardiomyogenic differentiation by inhibiting a positive transcriptional auto-feedback loop of Wnt3a.
Stem Cells 2008;26(1) 35-44 (corresponding author) [PMID 17916803]

Mirotsou M, Zhang Z, Deb A, Zhang L, Gneechi M, Noiseux N, Mu H, Pachori A, Dzau V. Sfrp2 mediates the paracrine survival signal of Akt genetically modified mesenchymal stem cell for myocardial protection and repair.
Proc Natl Acad Sci U.S.A 2007 104(5):1643-8 [PMID 17251350]

Noiseux N, MD, Gnecchi M, Lopez-Ilasaca M, Zhang L, Solomon S, Deb A, Dzau V, Pratt R. Mesenchymal stem cells over-expressing Akt dramatically repairs infarcted myocardium and improves cardiac function despite infrequent cellular fusion or differentiation.
Molecular Therapy 2006;(6):840-50 [PMID 16965940]

Friday B, Deb A. Systemic complications of Infective Endocarditis.
Circulation 2005; 112(20) e324 [PMID 16286596]

Wolk R, Deb A, Caplice NM, Virend K. Somers. Leptin receptor and functional effects of leptin in ‘late outgrowth’ human endothelial progenitor cells.
Atherosclerosis 2005; 183(1):131-139 [PMID 15950978]

Miller D, Deb A*, Edwards W, Zehr K, Oliveira A. Primary synovial sarcoma of the mitral valve.
Cardiovasc Pathol 2005; 14(6): 331-333 (*co first author) [PMID 16286044]

Deb A, Wang S, Skelding K, Miller D, Simper D, Caplice N. Bone Marrow derived myofibroblasts are present in adult human heart valves.
J Heart Valve Dis 2005;14:674-678 [PMID 16245507]

Liu C, Wang S, Deb A et al. Pro-apoptotic, anti-migratory, anti-proliferative and anti-angiogenic effects on human endothelial cells and endothelial progenitor cells in vitro. Implications of presence of sodium azide in commercial preparation.
Circ Res  2005:97(2) 135-143 [PMID 15976313]

Caplice N, Deb A. Myocardial Cell Replacement. The Science, the Clinic and the Future.
Nat Clin Pract Cardiovasc Med  2004.1(2):90-95 [PMID 16265312]

Deb A, Skelding K, Wang S, Reeder M, Simper D, Caplice N. Integrin profile and in vivo homing of human smooth muscle progenitor cells.
Circulation 2004;110:2673-2677 [PMID 15313945]

Deb A, Caplice N. Lipoprotein a: New insights into mechanisms of atherogenesis and thrombosis.
Clin Cardiol. 2004;27:258-264 [PMID 15188938]

Deb A, Tefferi A. Systemic Mastocytosis. [Images in Clinical Medicine]
N Engl J Med. 2003. 349(7); e7 [PMID 12917319]

Simper D, Wang S, Deb A et al. Endothelial progenitor cells are decreased in blood and endothelial cells of non cardiac origin are enriched in transplant atherosclerosis of cardiac subjects with vasculopathy.
Circulation  2003. 107: 143-149 [PMID 12835206]

Deb A, Wang S, Skelding KA, Simper D, Caplice NM. Bone Marrow-Derived Cardiomyocytes Are Present in Adult Human Heart. A study in gender mismatched bone marrow transplantation patients.
Circulation. 2003;107(9):1247-49 [PMID 12628942]

Young A.L, Baysal B.E, Deb A, Young W.F. Jr. Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene.
J Clin Endocrinol Metab. 2002;87(9):4101-5 [PMID 12213855]

Deb A, Natt N. 68-year-old man with generalized weakness.
Mayo Clin Proc. 2002; 77(7):705-8 [PMID 12108608]