Cardiac Repair & Regeneration

Journal of Clinical Investigation (2021)
Journal of Clinical Investigation (2021)

Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

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Cell (2020)
Cell (2020)

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury.

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Nature (2014)
Nature (2014)

Mesenchymal-endothelial transition contributes to cardiac neovascularization

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Journal of Clinical Investigation (2021)
Journal of Clinical Investigation (2021)

Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair

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Welcome to the Deb Laboratory at the David Geffen School of Medicine, UCLA. Our laboratory investigates molecular mechanisms driving tissue repair and regeneration especially in the heart. We examine mechanisms of wound healing and how the extracellular matrix, heart muscle cells and scar forming cells (fibroblasts) heart interact and regulate an acute or chronic injury response. The goal of our research is to enhance heart repair and regeneration after heart attacks. We adopt genetic, pharmacologic and physiologic approaches and use murine models as well as human tissue to address our questions. Our goal is to identify novel therapeutic approaches for enhancing repair of the heart and other tissues following injury.