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Cardiac Repair & Regeneration
Science (2023)
Immunofluorescent staining demonstrating fibroblasts expressing the Channelrhodopsin protein in heart scar tissue. The ChR2-expressing fibroblast (green) is in close proximity to cardiomyocytes (red) within scar.
Journal of Clinical Investigation (2021)
Cardiomyocytes disrupt pyrimidine biosynthesis in nonmyocytes to regulate heart repair
Nature (2014)
Mesenchymal-endothelial transition contributes to cardiac neovascularization
Science (2023)
Immunofluorescent staining demonstrating fibroblasts expressing the Channelrhodopsin protein in heart scar tissue. The ChR2-expressing fibroblast (green) is in close proximity to cardiomyocytes (red) within scar.
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Welcome to the Deb Laboratory at the David Geffen School of Medicine, UCLA. Our laboratory investigates molecular mechanisms driving tissue repair and regeneration especially in the heart. We examine mechanisms of wound healing and how the extracellular matrix, heart muscle cells and scar forming cells (fibroblasts) heart interact and regulate an acute or chronic injury response. The goal of our research is to enhance heart repair and regeneration after heart attacks. We adopt genetic, pharmacologic and physiologic approaches and use murine models as well as human tissue to address our questions. Our goal is to identify novel therapeutic approaches for enhancing repair of the heart and other tissues following injury.
IN THE NEWS
Yijie Wang, PhD Selected as One of Eight Awardees for the 2023 Chancellor's Award for Postdoctoral Research
Director of the Cardiovascular Research Theme, Dr. Deb, hosted the annual Cardiovascular Research Theme Retreat in October 2023. With over 200 attendees and guest speakers from around the nation, the symposium was highly successful and we look forward to next year!
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