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MRL 3609
675 Charles E. Young Drive,
Los Angeles, CA 90095
Now Hiring
Project Scientist Series Position in Cardiology
We are seeking a staff scientist to lead our protein biochemistry and biologics production efforts — building and operating a robust in-house capability for recombinant protein expression, purification, and characterization to accelerate our biologics pipeline from bench to clinic.
Key Responsibilities
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Design, optimize, and execute mammalian recombinant protein expression using HEK293, CHO, or equivalent systems
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Purify proteins using affinity chromatography, SEC, and ion exchange on FPLC/ÄKTA platforms
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Perform quality characterization including SDS-PAGE, western blot, ELISA, DLS, and binding validation by SPR or BLI
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Collaborate with postdoctoral scientists on protein-dependent experimental aims
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Evaluate and implement new expression and purification technologies as the pipeline evolves
Qualifications
Required
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PhD or equivalent in biochemistry, protein biochemistry, molecular biology, or a closely related field
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Minimum 5 years of hands-on experience with mammalian recombinant protein expression and purification — bacterial expression experience alone is not sufficient
Preferred
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Industry experience in a biologics, biotech, or pharmaceutical setting
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Experience with antibody production, engineering, or optimization
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Familiarity with GMP-adjacent processes and regulatory documentation
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Experience with binding kinetics platforms (Biacore/SPR, BLI/Octet)
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Background in cardiovascular biology, immunology, or metabolic disease
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Expert-level proficiency with FPLC/ÄKTA chromatography systems
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Strong working knowledge of protein QC methods (SDS-PAGE, SEC-HPLC, ELISA, DLS)